Treatments

Rejuran Injection (Rejuran Healer)

Results & Korea Price

Written by BeautyCoordi Editorial TeamMedically reviewed by Dr. Park HwonhamDR.BAQUO4 min read

Rejuran Injection (Rejuran Healer): 3D illustration of how it works

Rejuran is a Korean skin booster that injects purified salmon DNA fragments (PN) into the dermis to help skin repair itself. It is not a filler: the goal is smoother texture, softer fine lines and firmer skin, built up over a course of sessions.

Rejuran at a glance

  • Best for: rough texture, fine lines, thin or tired-looking skin
  • Sessions: usually 3 sessions, at least 3–4 weeks apart, then maintenance every few months
  • Downtime: small bumps for about a day; bruises, if any, 1–2 weeks; go easy on makeup for 2–3 days
  • Not for: adding volume or lifting sagging contours

What results can you expect from Rejuran?

Patients usually describe their skin as smoother, softer and with more of a glow. Changes build gradually: one session can make skin feel more hydrated, but texture and firmness improve more clearly over the first course.

Dull skin with fine lines (before) → a very fine needle places small amounts closely across the cheeks and under the eyes (injection) → raised bumps right after that usually settle in about a day (right after) → skin texture smooths and fine lines soften over a course of sessions (after sessions).

A very fine needle places small amounts of PN in the upper dermis, where it spreads and stimulates the surrounding fibroblasts. Illustration of the mechanism.

How it works:

  1. Injection: tiny amounts are placed in the upper dermis, densely across the face.
  2. Signal: as PN breaks down, it acts on fibroblasts (through the adenosine A2A receptor), which is thought to support collagen production and calm inflammation.
  3. Repair: the skin's support structure fills in little by little over several weeks.

Much of this mechanism comes from cell and animal studies, so the honest way to think about Rejuran is "a treatment that helps skin recover", not a dramatic transformation. In a Korean randomized trial around the eyes, PN injections performed about as well as hyaluronic acid injections overall and improved roughness and pores more.

How many sessions, and how far apart?

After sessions — Dull texture after a course of sessions, shown on a 3D face model. Usually about three sessions three to four weeks apart; the change builds gradually. Illustration of the mechanism.BeforeBeforeAfter sessions
↔ Drag to compareDull texture after a course of sessions, shown on a 3D face model. Usually about three sessions three to four weeks apart; the change builds gradually. Illustration of the mechanism.
After 3 sessions — The upper dermis becomes denser and the surface smoother. In a Korean randomised trial (Lee 2022), PN injections improved skin roughness and pores. Rejuran does not add volume or lift. Illustration of the mechanism.BeforeBeforeAfter 3 sessions
↔ Drag to compareThe upper dermis becomes denser and the surface smoother. In a Korean randomised trial (Lee 2022), PN injections improved skin roughness and pores. Rejuran does not add volume or lift. Illustration of the mechanism.
PhaseTypical plan
First course3 sessions, at least 3–4 weeks apart
When you notice itoften around the 2nd–3rd session
Maintenanceevery few months, depending on your skin

Not sure how many sessions your skin needs? Ask us before you book your trip.

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Getting Rejuran in Korea: planning your trip

Because sessions are spaced at least three to four weeks apart, a short trip usually fits one session. Common ways to plan it:

  • One session per visit: come back three to four weeks later, or on your next trip.
  • Book it early in your stay: bumps usually settle in about a day, but bruises can last longer, so avoid the day before photos, events or your flight home.
  • Combine with lifting: if you are also getting Ultherapy, Shurink or a laser, Rejuran is done last on the same day.

Does Rejuran hurt?

Yes, more than most skin boosters. Thin areas such as the forehead and around the eyes and mouth are the most sensitive.

  • Numbing cream: applied for 40–60 minutes before starting
  • Injector device: a machine designed to make the injections less painful
  • Sedation: an option for patients who are very anxious about pain

Downtime, side effects and makeup

ReactionUsually lasts
Small raised bumps at injection pointsabout a day
Redness and swellinghours to a few days
Bruising1–2 weeks, if it happens

Rarely, infection, firm nodules or allergic reactions can occur. Every treatment has some risk, so tell the clinic straight away if swelling or pain lasts.

Tell the clinic first if you are allergic to fish or salmon, have inflammation or a skin condition in the area, are pregnant or breastfeeding, or take medicine that makes you bleed easily.

Rejuran, Rejuran Eye or Rejuran S?

ProductWhat is differentUsed for
Rejuran Healerthe originaltexture, fine lines and firmness across the face
Rejuran Eyelower viscosity, spreads in thin skinfine lines, friction pigmentation and dark circles under the eyes
Rejuran Smade for scarsdepressed acne scars

Rejuran Eye's volume effect is temporary. If the under-eye area looks hollow from lost volume, a volume treatment is usually the better fit.

How much does Rejuran cost in Korea?

Prices vary between clinics because the conditions vary. Compare these on the same basis:

  1. How many cc are used (full face or a smaller area)
  2. Whether a sealed, genuine product is opened in front of you
  3. Whether numbing and soothing care are included
  4. For event prices, conditions such as first visit only or session limits

If price matters most, other brands with the same PN ingredient can be a more affordable alternative. Current package prices, including clinic visit support in English, are listed on the DR.BAQUO packages page.

Rejuran with Ultherapy, Shurink or lasers

Lifting treatments work on contour, and Rejuran works on the skin itself, so many patients combine them.

FAQ

Is one Rejuran session enough?

One session can make skin feel smoother and more hydrated, but texture and firmness usually change more clearly after the first course of three.

Are Rejuran results permanent?

No. Skin keeps ageing, so most people continue with maintenance sessions every few months after the first course.

Is salmon DNA safe?

Rejuran uses purified PN and is sold as a medical device product. Studies so far mostly report mild reactions, but they are small and short, so mention any fish allergy before treatment.

Sources

  1. Lampridou S et al. The Effectiveness of Polynucleotides in Esthetic Medicine — A Systematic Review. J Cosmet Dermatol, 2025
  2. Lee YJ et al. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation — a randomized, double-blind, split-face trial. J Dermatolog Treat, 2022
  3. Park KY et al. Long-chain polynucleotide filler for skin rejuvenation — efficacy and complications in five patients. Dermatol Ther, 2016
  4. Marques C et al. From PDRNs to PNs — Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications. Biomolecules, 2025

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This page is general information, not medical advice. Decide on any treatment after consulting a medical professional.